EE497 Real-World Healthcare Resource Utilization and Associated Costs in Patients with Eosinophilic Esophagitis

Eosinophilic esophagitis (EoE) has rapidly become a major cause of upper gastrointestinal morbidity and associated financial burden. Related evidence on healthcare resource utilization (HCRU) costs is sparse. We aimed to evaluate HCRU in patients with EoE. This matched case-control study used US medical pharmacy claims from the Optum Clinformatics database (1/1/08–9/30/20) identify EoE (cases) controls (no EoE). Index date was defined as first diagnosis (index period: 1/1/09–9/30/19). Cases ≥2 diagnostic continuous enrollment ≥1 year before after index were eligible. Incidence density sampling match 1:4 by age, sex, region, Charlson Comorbidity Index. Inpatient, outpatient, emergency room, settings evaluated. Baseline characteristics analyzed for cohorts. All-cause per patient month (PPPM) visits (1000 [1000PPM]) compared. A generalized linear model estimated effect costs. identified 13,129 cases 43,338 (mean age 37 years, 65% male). had higher versus ($800.39 vs $402.81 PPPM) more (1986.2 1168.4 1000PPM) at baseline 12 months (costs: $1184.73 $463.25 PPPM; visits: 2535.8 1220.3 1000PPM). Incremental $581.15 PPPM, primarily driven outpatient ($349.22 PPPM). Pharmacy ($75.34 PPPM), inpatient ($57.51 room (ER) ($10.67 also cases. Additionally, 388.8 visits, 14.7 ER 2.8 (1000PPM). All incremental effects statistically significant. Patients experience significantly economic burden evidenced total across settings, especially setting.